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Cat. No. | Product Name | Target | Signaling Pathways |
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T27478 |
GSK3987
|
Liver X Receptor | Metabolism |
GSK3987 是广谱LXRα/β激动剂,EC50分别为 50 nM 和 40 nM。GSK3987增加 ABCA1 和 SREBP-1c 蛋白的表达,诱导细胞甘油三酯的积累和胆固醇流出。 | |||
T41008 |
BODIPY-Cholesterol
BCh2 |
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BODIPY-Cholesterol (TF-Chol)是一种带有荧光 BODIPY 基团和细胞通透性的胆固醇类似物,是一种新型 BODIPY 胆固醇探针。BODIPY-Cholesterol 可用于研究细胞内固醇摄取和细胞器间固醇通量。 | |||
T36126 |
TMP-153
|
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Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals. TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals. At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduc... | |||
T24855 |
TASIN-1 Hydrochloride
塔辛-1盐酸盐,TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl |
APC | Cell Cycle/Checkpoint |
TASIN-1 Hydrochloride (TASIN-1 HCl) 是一种截短型 APC 的选择性抑制剂,通过降低细胞胆固醇水平和通过结肠癌细胞中的 ER 应激/ROS/JNK 信号传导诱导凋亡细胞死亡来选择性杀死表达截短型 APC 的结肠直肠癌细胞。 | |||
T83658 |
SQLE-IN-1
|
Antifungal | Microbiology/Virology |
SQLE-IN-1 是一种角鲨烯环氧化酶 (SQLE) 抑制剂,具有抗肿瘤活性,可抑制肝癌细胞系 Huh7 的增殖和迁移能力,抑制细胞胆固醇的生成,增加抑癌基因PTEN的表达,抑制PI3K和AKT的蛋白表达。 | |||
T19159 |
Mal-β-CD
6-O-alpha-D-Maltosyl-beta-cyclodextrin |
Others | Others |
Mal-β-CD is a cellular cholesterol modifier. It can form a soluble inclusion complex with cholesterol. | |||
T37846 | Taurohyocholic Acid (sodium salt) | ||
Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.2It prevents cholestasis and cellular necrosis induced by taurolithocholic acid in isolated rat livers.3THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.4 | |||
T25356 |
E17110
E-17110,E 17110 |
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E17110 is an LXRβ agonist. E17110 exhibited a significant activation effect on LXRβ (EC50: 0.72 μmol/L). E17110 also increased the expression of ABCA1 and ABCG1 in RAW264.7 macrophages. E17110 significantly decreased cellular lipid accumulation and promoted cholesterol efflux in RAW264.7 macrophages. | |||
T37853 |
Cholesteryl Lignocerate
|
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Cholesteryl lignocerate is a cholesterol ester that has been found in human meibum. Cholesteryl lignocerate can be hydrolyzed by cellular extracts from cultured human skin fibroblasts isolated from healthy individuals but not patients with cholesteryl ester storage disease (CESD) or Wolman disease. | |||
T13483 |
RP 54275
2-Octadecyl-1H-indole-5-carboxylic acid |
Others | Others |
RP 54275 是一种天然存在的脂肪酸衍生物,一种新的降胆固醇化合物。它可以激活过氧化物酶体增殖物激活受体γ(PPARγ)途径,该途径参与脂质代谢、炎症和细胞分化的调节。 | |||
T37953 |
Sphingomyelins (buttermilk)
|
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Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling... | |||
T76156 | Sphingomyelin phosphodiesterase | ||
Sphingomyelinphosphodiesterase 是一种水解酶,参与鞘磷脂代谢过程。Sphingomyelinphosphodiesterase 水解鞘磷脂,使其向磷酸胆碱和神经酰胺转化。Sphingomyelinphosphodiesterase 还在细胞分化、各种免疫和炎症反应以及细胞内胆固醇运输和代谢中发挥重要作用。 | |||
T83683 |
st-Ht31 ammonium
sHt31 |
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st-Ht31是一种由A-kinase锚定蛋白(AKAPs)的两亲螺旋域衍生的、可穿透细胞的硬脂化肽,它能够结合蛋白激酶A (PKA)。在使用50 µM浓度时,能降低PKA在细胞膜上的锚定,但不影响其在使用BHK-21成纤维细胞进行的报告基因分析中的活性。st-Ht31 (1和3 µM)能减少小鼠精子的电容和超活化,同时阻止体外受精。当使用50 µM浓度时,它还能促进表达ATP结合盒转运蛋白1 (ABCA1)的BHK-21细胞和RAW 264.7巨噬细胞中的胆固醇排出。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN4016 |
Ethyl 2,4,6-trihydroxybenzoate
|
Liver X Receptor | Metabolism |
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes. |